Micronutrients – potential food components against neurodegenerative diseases



Aim:
Alzheimer disease (AD) is the most common form of dementia with yet unknown cause. Despite intensive research, AD is not curable yet. It is only possible to treat symptoms, slowing but not stopping the progression of the disease. One of the hallmarks of AD is mitochondrial dysfunction. A possible way to slow down the process could be the additional administration of vitamins and trace elements. Vitamins and trace elements are vital for our body and are indispensable for many functions. There is evidence that supplementation may delay the onset of AD.

Background: 
The aim of this project is to analyze different micronutrients for their potential to imporove mitochondrial dysfunction in cellular models of early AD (SH-SY5Y-APP695 cells and SH-SY5Y-P301L tau cells). 

Links:
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References:

  • Vlachos GS, Scarmeas N (2019) Dietary interventions in mild cognitive impairment and dementia. Dialogues Clin Neurosci 21(1): 69–82.
  • Fenech M (2017) Vitamins Associated with Brain Aging, Mild Cognitive Impairment, and Alzheimer Disease: Biomarkers, Epidemiological and Experimental Evidence, Plausible Mechanisms, and Knowledge Gaps. Adv Nutr 8(6): 958–970.
  • Eckert GP (2019) Role of Vitamin E in Aging and Alzheimer`s Disease. In: Vitamin E in Human Health (Eds. Weber P, Birringer M, Blumberg JB, Eggersdorfer M, Frank J), Humana press, 2019, ISBN 978-3-030-05315

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© Prof. Dr. Gunter P. Eckert 2018